AKT1 and neoplasm: Similarly, in vitro (SK-hep1 and SM-7721 cells) and in vivo (inoculation of SK-hep1 into mice) studies have shown that the combination of sorafenib and ART significantly promoted tumor cell apoptosis through the inhibition of the RAF/MAPK and PI3K/AKT/mTOR pathways, which in turn exerted anti-cancer effects [140].