In both in vitro (HepG2 and MHCC-97H cells) and in vivo (a rat model with HepG2 cells) experiments, it was found that ART could promote the apoptosis of tumor cells in a manner that increased with the amount used, whereas a combination with GBA activators reversed the effects of ART; ART also facilitated the transformation of LC3B-I into LC3B-II, increased the levels of SQSTM1/p62, decreased GBA protein levels, and markedly elevated the count of autophagosomes within HCC cells. Here, SQSTM1 is linked to hepatocellular carcinoma.