On the other hand, experiments in a rodent model of AD demonstrated that BECs have a decrease in the Wnt pathway, and its restoration prevents BEC impairment, as Wnt signaling increases the expression of TJ-related genes such as claudin-5 and ZO-1; likewise, Wnt signaling also restores BEC impermeability [24]. The gene discussed is TJP1; the disease is Alzheimer disease.