IL13RA2 and central nervous system cancer: Additionally, Lv and colleagues studied a novel paclitaxel-modified nanoparticle (PC-NP-PTX) that combines Pep-1 and CGKRK peptide for the dual-targeted chemotherapy of glioma cells and neovasculature, utilizing a high expression of IL-13Rα2 on glioma cells and heparan sulfate on endothelial cells to achieve a brain-targeted delivery [168].