Another cut-off value was employed by Fons et al. (2009), who defined three groups according to the immunohistochemical cell count—“negative” in the case that less than 10% of nuclei stain positive, “weak positive” if up to 50% show positive nuclear staining, and “strong positive” if >50% of tumor nuclei are ki-67-positive [58]. This evidence concerns the gene MKI67 and neoplasm.