MKI67 and neoplasm: Indeed, within the examined study cohort, only the two oldest studies determined no significant correlation of tumor grade with a distinct ki-67 staining pattern (Hendricks et al. (p = 0.545) and Marchetti et al. [49,52]), whereas the remaining groups described an association of well-differentiated tumors with focal / basal staining patterns (Salmaso et al. (Spearman’s Rho = 0.344, p = 0.0001), and Hantschmann et al. (p = 0.024)) and consistently found a correlation of poor tumor differentiation with diffuse ki-67 staining pattern (Modesitt et al. (p = 0.013, CI 1.59 –7.60) [53,54,56].