For this study, medical libraries were systematically screened for literature regarding ki-67 staining in vulvar cancers, and relevant study results were depicted to examine and summarize existing knowledge about the prognostic relevance of ki-67 immunohistochemistry with regard to lymph node metastasis and survival data in squamous cell carcinoma of the vulva. This evidence concerns the gene MKI67 and vulvar squamous cell carcinoma.