Two studies aimed at the comparison of ki-67 with alternative proliferative markers/activity; Brustmann et al. looked at nucleolar organizer regions and Topoisomerase II-alpha visualizations and did not determine a significant association of one of these proliferation markers with survival data; meanwhile, Emanuels et al. evaluated the ki-67 cell count, the proliferation marker Ag-NOR, and the mitotic index, but did not find an association of any proliferative markers with inguinofemoral lymph node metastases [51,57]. Here, MKI67 is linked to metastatic malignant neoplasm in the lymph nodes.