Wild-type transthyretin cardiac amyloidosis (wtTTR-CA) represents an underdiagnosed cause of HFpEF typical of advanced age (the median age at diagnosis is >70 years) [197], as up to 16% of patients over 65 years old with cryptogenic left ventricular hypertrophy (LVH) or HFpEF or severe aortic stenosis may have wtTTR-CA [22]. This evidence concerns the gene TTR and cardiac amyloidosis.