Accordingly, for patients with AF, higher cut-off values have been applied as diagnostic of HFpEF: NT-proBNP > 660 pg/mL and BNP > 240 pg/mL are major criteria, while NT-proBNP 375–660 pg/mL and BNP 105–240 pg/mL are minor. The gene discussed is NPPB; the disease is atrial fibrillation.