The association between low eGFR and SGLT2-induced urinary tract infections is complex; on the one hand, with worsening renal function, SGLT2-induced glycosuria decreases, so lower eGFR could be protective for infections at this level; on the other hand, urinary tract infections in this group of patients could result from impaired host defense mechanisms with chronic kidney disease, considerations that could apply to other risk factors such as age and proteinuria [42,47]. The gene discussed is SLC5A2; the disease is chronic kidney disease.