To explore the clinical significance of F2RL1, P2RX2, P2RX3 and P2RY2 expression in GERD, the correlation between the level of F2RL1, P2RX2, P2RX3 and P2RY2 genes and the GERD-HRQL questionnaire score was investigated. This evidence concerns the gene P2RX3 and gastroesophageal reflux disease.