To explore the clinical significance of F2RL1, P2RX2, P2RX3 and P2RY2 expression in GERD, the correlation between the level of F2RL1, P2RX2, P2RX3 and P2RY2 genes and the GERD-HRQL questionnaire score was investigated. The gene discussed is F2RL1; the disease is gastroesophageal reflux disease.