LTF and chronic periodontitis: In another recently published case-control study, Ramenzoni et al. [21] demonstrated that in individuals with Stage III Grade B chronic periodontitis, the concentration of lactoferrin in stimulated saliva can be up to three times higher compared to periodontally healthy individuals (median [IQR]: 28.5 [3.5] μg/mL versus 9.6 [1.8] μg/mL).