The patient was a 57-year-old male with T1DM complicated by neuropathy, nephropathy, proliferative diabetic retinopathy, and cerebrovascular accident (CVA) with a history of hypoglycemia and hypoglycemia unawareness who was not reaching the recommended amount of TIR after ongoing follow-up, insulin adjustments, and education efforts. The gene discussed is INS; the disease is type 1 diabetes mellitus.