In this context, to avoid the risks deriving from the use of a highly pathogenic and contagious virus, the involvement of AhR response during infection with BCoV, a βCoV-like SARS-CoV-2, and the activity of a selective AhR ligand (CH223191, Figure 1) were evaluated by in vitro studies and by the application of an integrated approach based on the combination of computational techniques such as homology modeling and molecular docking. This evidence concerns the gene AHR and infection.