The use of laboratory tests, including positive blood culture, ESR (erythrocyte sedimentation rate) and CRP (C-reactive protein), as well as diagnostic imaging, such as MRI, CT, nuclear magnetic imaging, ultrasound or X-ray, and biopsies, supports the diagnosis: (a) clinical signs of osteomyelitis, (b) positive blood cultures, (c) radiological support. The gene discussed is CRP; the disease is osteomyelitis.