Recent studies have highlighted the role of genetic alterations that play a key role in nephroblastoma pathogenesis, in particular, mutations in key regulatory genes such as WT1, WT2, CTNNB1, WTX, and TP53, which are associated with the development and progression of nephroblastoma tumors [96,99,126,127]. Here, WT1 is linked to Nephroblastoma.