A pT2b poorly differentiated carcinoma of the gallbladder with squamocellular (SCC) differentiation was identified [immunophenotype: high molecular weight cytokeratin + (CKHMW), AE1-AE3 +, epithelial membrane antigen + (EMA), cytokeratin 7 − (CK7), synaptophysin-], distant from the site of perforation. Here, MUC1 is linked to gallbladder carcinoma.