White et al. conducted a systematic review and meta-analysis with pooled analysis revealing that all-cause mortality in AS was significantly associated with higher levels of BNP (HR 2.59, [95% CI 1.95–3.44], p < 0.00001), NT-proBNP (HR 1.73, [95% CI 1.45–2.06], p = 0.00001), Troponin (HR 1.65, [95% CI 1.31–2.07], p < 0.0001) and Galectin-3 (HR 1.82, [95% CI 1.27–2.61], p < 0.001) [51]. The gene discussed is NPPB; the disease is aortic stenosis.