Secondly, ablation was also found to stimulate the release of pro-inflammatory cytokines and chemokines such as Interferon gamma (IFNγ); these cytokines and chemokines further shift the tumour microenvironment from “cold” (immunosuppressive) to “hot” (immunostimulatory) and facilitate the recruitment of antigen-presenting cells (APCs) [87,89]. The gene discussed is IFNG; the disease is neoplasm.