Minor criteria include the following: (a) eruption is preceded by a non-specific respiratory/gastrointestinal infection, inflammatory/autoimmune disorder, neoplasia, or pregnancy; (b) periods of general malaise and fever (>38 °C); (c) raised ESR > 20 mm, raised CRP, and leukocytosis; (d) excellent response to treatment with systemic corticosteroids or potassium iodide. The gene discussed is CRP; the disease is Increased total leukocyte count.