Ulmner et al. reported a correlation between TMJ palpation pain and TNF- α and IL-1β in synovial tissue of patients with internal TMJ derangement [50], while Ernberg et al. reported an association between plasma levels of IL-7 with pain catastrophizing, and plasma levels of IL-6 with pain duration in TMD myalgia patients [41]. This evidence concerns the gene IL6 and Myalgia.