STAT3 and breast cancer: The involvement of CXCR4/CXCL12 in the growth and metastasizing mechanism of breast cancer through the activation of the JAK2/STAT3 pathway has also been demonstrated, highlighting how the simultaneous expression of CXCR4 and p-STAT3 at the tissue level results in a link to tumor size, lymph node metastasis, and histological tumor grade [33].