However, AMD11070 has also been demonstrated to be effective in melanoma; in fact, both AMD3100 and AMD11070 significantly blocked the chemotaxis of CHL-1 cells (melanoma human cell line) towards CXCL12, but AMD11070 showed to be more effective at inhibiting the migration of the melanoma cell line A375 than AMD3100 (78% vs. 21% inhibition, respectively) [69]. This evidence concerns the gene CXCL12 and melanoma.