Shi et al. demonstrated that baicalin mitigated nonalcoholic steatohepatitis (NASH) in an HFD mouse model, reducing lipid accumulation, inflammation, and oxidative damage in liver tissues, partly by enhancing NRF2/HO-1 expression and suppressing the NLRP3/Caspase1/GSDMD-mediated pyroptosis pathway. The gene discussed is NLRP3; the disease is metabolic dysfunction-associated steatohepatitis.