Regarding TRAF2, somatic mutations in TRAF2 have been detected in diffuse large B-cell lymphoma [65]; the knockdown of TRAF2 suppressed the proliferation of human breast carcinoma cells [66,67], and liquidambaric acid inhibited colon carcinoma cells by directly targeting TRAF2 [68]. This evidence concerns the gene TRAF2 and colon carcinoma.