SOD1 and amyotrophic lateral sclerosis: The inflammatory Fe2+/ROS/NF-κB pathway is a crucial link between iron metabolism, cellular inflammation, and ALS; in particular, astroglial and microglial activation in ALS have been associated with LPS-induced inflammation, and LPS injection has been shown to increase the nuclear expression of the CCAAT/enhancer-binding protein δ (C/EBPδ), a transcription factor involved in growth arrest and differentiation whose gene is associated with familial ALS in the spinal cord of G93A-SOD1 mice [178,179].