Although there are no experiments or conclusive data, the fact that NCOA4 is directly implicated in ferritinophagy potentially correlates ferroptosis with ALS, as it is known that neuronal areas such as the putamen, substantia nigra, caudate nucleus, and red nucleus are very susceptible to dysregulated iron levels, and thus to the generation of neurodegenerative diseases like ALS [159,160]. This evidence concerns the gene NCOA4 and amyotrophic lateral sclerosis.