TARDBP and amyotrophic lateral sclerosis: It has been shown that SOD1, TDP-43, FUS, C9ORF72, and the dipeptide repeater protein glycine/arginine (GR), associated with the expansion of the GGGGCC repeat (DPR) C9ORF72, interfere with mitochondria, causing their alteration in cases of ALS [51].