SLC1A2 and amyotrophic lateral sclerosis: The link between ALS and altered glutamate transmission is potentially explained through the involvement of astrocytes; in fact, these cells, under normal conditions, are equipped with an excitatory amino acid transporter system 2 (EAAT2) for glutamate; in pathological conditions, on the other hand, the presence of EAAT2 is lower, and this does not allow the reabsorption of the neurotransmitter.