In a study by Miñana G. et al., which analyzed 2949 patients admitted for acute HF, five factors were identified as being associated with elevated CA-125—the presence of pleural effusion, the severity of tricuspid regurgitation, age, NT-proBNP levels, and peripheral edema (4.3%)—all of which are typically present in right-dominant HF [27]. The gene discussed is NPPB; the disease is tricuspid valve insufficiency.