IRS-1 (24.33 ± 1.76% of control) and Akt (6.07 ± 1.46% of control) protein expression in liver tissue were downregulated in metabolic syndrome rats compared to normal rats (100 ± 0.00% of control), (100 ± 0.00% of control) (p < 0.05). The gene discussed is IRS1; the disease is metabolic syndrome.