Supplementation with tangeretin (43.04 ± 5.98% of control), (44.30 ± 5.09% of control), and metformin (41.80 ± 3.48% of control), (52.53 ± 12.66% of control) recovered IRS-1 and Akt protein expression compared to untreated metabolic syndrome rats (p < 0.05, Figure 6). This evidence concerns the gene IRS1 and metabolic syndrome.