Tangeretin and metformin administration significantly improved insulin sensitivity by reducing fasting blood glucose (96.16 ± 3.79 mg/dL), (102.66 ± 2.59 mg/dL), fasting serum insulin (90.37 ± 22.26 μU/mL), (173.85 ± 19.18 μU/mL), and HOMA-IR index (25.50 ± 7.66), (44.83 ± 3.92), and adiponectin level (50.17 ± 1.55 ng/mL), (58.94 ± 1.95 ng/mL) in metabolic syndrome rats (p < 0.05) compared to the untreated group (Figure 2). Here, INS is linked to metabolic syndrome.