Recent studies have shown that the use of auto-probiotics based on non-pathogenic strains of Enterococcus faecium and Enterococcus hirae as personalized functional food products (PFFPs) in the complex therapy of early-stage CRC reduced dyspeptic symptoms, postoperative complications, and serum levels of proinflammatory cytokines (IL-6 and IL-18) [18]. Here, IL18 is linked to colorectal carcinoma.