ESR1 and melanoma: In 2015, Marzagalli et al. reported that ERβ (but not ERα) is expressed in four types of melanoma cell lines (BLM, WM115, A375, WM1552) that have various genetic mutations, and it exhibits antitumor effects in BLM (NRAS-mutant) and WM115 (BRAF V600D-mutant) cells [8].