ESR2 and neoplasm: Moreover, E2 plays an important role in the growth and differentiation of normal tissues as well as different types of neoplasms, like breast, ovarian, endometrial, prostate, lung, kidney, pancreas, colon, brain, adrenals, and bone by binding to two specific estrogen receptors (ERs): ERα and ERβ which are members of the nuclear steroid hormone receptor superfamily [3].