SIRT1 and metabolic disease: Unlike conventional database searches, the present study determined five absorbed prototype metabolites of DBT using serum pharmacochemistry: formononetin, kaempferol 3-glucuronide, nicotinic acid, amygdalin, and soyasaponin I. Formononetin, derived from Astragali Radix, has been shown to alleviate the metabolic disorder of lipids by modulating the SIRT1 and PPARα pathways [33,34].