Additionally, while this study focused on the MAPK pathway, other signaling pathways implicated in NSCLC metastasis, such as the PI3K/AKT, NF-κB, and Wnt/B-catenin pathways, should be investigated to comprehensively elucidate the mechanism of action of these compounds. This evidence concerns the gene NFKB1 and non-small cell lung carcinoma.