BDNF and major depressive disorder: Also, lurasidone was shown to modulate synaptic and neuroplastic proteins in an experimental model of depression, potentially restoring BDNF mRNA in the prefrontal cortex and normalizing levels of glial fibrillary acidic protein (Gfap), postsynaptic density protein 95 (Psd95), and certain regulators of protein translation at the synapse, such as mTOR and eukaryotic elongation factor 2 (EEF2) [128].