A meta-analysis of 10 studies involving 6244 patients with HF showed the association of GDF-15 with the risk of all-cause mortality among patients with chronic ischemic HF (HR: 1.75, 95%CI: 1.24–2.48, p = 0.002), while this association was not found among patients with chronic nonischemic HF (HR: 1.01, 95%CI: 1.00–1.02, p = 0.219) [29]. The gene discussed is GDF15; the disease is hydrops fetalis.