Accordingly, we found higher Aβ burden in the hippocampus of female mice compared to male mice at 12 months of age, as well as reduced CBF, particularly in female APP/PS1 compared to their male littermates in the ipsilateral thalamus (0.5 months post-stroke) and in the hippocampus (8 months post-stroke). This evidence concerns the gene PSEN1 and stroke disorder.