On the contrary, in periodontitis (PD) caused by porphyromonas gingivalis (Pg), ApoVs derived from Mφ were found enriched with miR-143-3p, targeting insulin-like growth factor-binding protein 5 (IGFBP5), thereby disrupting periodontal bone homeostasis [45]. Here, IGFBP5 is linked to periodontitis.