Furthermore, all dedifferentiated liposarcomas (DDLPSs), well-differentiated liposarcomas (WDLPSs), and atypical lipomatous tumors (ALTs) present chromothripsis in the long arm of chromosome 12, where amplified CDK4, HMGA2, and MDM2 genes are localized. The gene discussed is CDK4; the disease is liposarcoma.