TP53 and undifferentiated pleomorphic sarcoma: In addition, deletions, SVs, and LOH regions of TP53 and RB1 have also been identified in several sarcoma subtypes, particularly in leiomyosarcomas, myxofibrosarcomas, and undifferentiated pleomorphic sarcomas, where they play a significant role in tumor oncogenesis and progression [44,45].