RBFOX3 and Alzheimer disease: To study the effect of TBG096 on neurogenesis in the cerebral cortex and hippocampus of AD mice, double-staining immunofluorescence analyses of NeuN and bromodeoxyuridine (BrdU) were performed, which are biomarkers for mature neurons and newborn neurons used to detect the changes in the cerebral cortex and hippocampus of AD mice.