Figure 5 presents the box plots for these three AAb for the total cohort and the female and male subgroups. The corresponding p-values and q-values indicate no significant difference between patients and controls, contrasting with previous studies that reported elevated levels of ADRB2 in ME/CFS [18,19]. Interestingly, within the male cohort, the trend is opposite, with lower AAb levels in the ME/CFS patients compared to controls, as shown in Figure 2. Here, ADRB2 is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.