CD274 and neoplasm: Inhibition of the PI3Kαδ and PI3Kγδ or PI3K-AKTmTOR pathway by the reduction in TNBC tumor hypoxia-sensitized TNBC to RT-mediated DNA damage suggests that the synergetic effects of RT and anti-PD-L1 therapy in CT26 murine colorectal carcinoma cells, TNBC cell and TNBC mouse models [141,142].