Compared with other breast cancer subtypes, the TME of TNBC is quite different because of the higher infiltration of TILs, TAMs, high expression of VEGF and other cytokine and chemokines [125], poor interaction between T cell PD-1 and tumor cell PD-L1, [126] and low response to ICIs monotherapy [127]. This evidence concerns the gene CD274 and breast carcinoma.