SPP1 and Dilatation of the cerebral artery: Plasma FL-OPN levels were significantly increased at all time points after SAH compared with control patients with unruptured intracranial aneurysms (951.56 pmol/L [734.75–1143.86, p < 0.001] at days 1–3; 956.96 pmol/L [697.92–1311.26, p < 0.001] at days 4–6; 876.09 pmol/L [688.47–1119.15, p < 0.001] at days 7–9; and 815.22 pmol/L [638.27–1208.21, p = 0.002] at days 10–12 versus 392.62 pmol/L [348.10–621.76] in controls; median [interquartile range, p value using Mann−Whitney U test]).