Hepatocytes express stress-induced ligands like MHC class I-related chain A/B (MICA/B) under damage, infection, or oncogenic stress [159], which are recognized by γδT cell NKG2D receptors, triggering cytotoxic responses via perforin and granzyme, and pro-inflammatory cytokine release (e.g., IFN-γ, TNF-α). The gene discussed is MICA; the disease is infection.