In a healthy state, γδT cells recognize non-MHC restricted antigens through TCR [215], such as phosphorylated metabolites (such as isopentenyl pyrophosphate, IPP) produced in the metabolic process of tumor cells, and activate rapidly to release cytotoxic molecules such as perforin and granzyme, which can directly kill tumor cells [61,216]. The gene discussed is PRF1; the disease is neoplasm.