Indeed, in VMAT2 floxed mice, the injection of a lentivial vector to specifically express Cre recombinase in PFC astrocytes, leading to the deletion of VMAT2 only in these astrocytes, recapitulated all the findings in aVMAT2 mice, from reduced DA levels and increased neuronal activity in the PFC to pathological grooming and anxiety-like behaviors. The gene discussed is SLC18A2; the disease is Anxiety.