While the recovery of excitatory transmission in mPFC brain slices was likely mediated by the rescue of GLT-1 expression in the mPFC, the systemic nature of the GLT-1 rescue tool used by the authors does not allow for an unambiguous conclusion that the effect on anxiety was mediated exclusively by the recovery of GLT-1 in the mPFC, as in other brain regions, basal levels of GLT-1 were likely increased. The gene discussed is SLC1A2; the disease is Anxiety.