The major component of the MICOS complex, MIC60, is a reported substrate of serine-/threonine-protein mitochondrial kinase 1 (PINK1), a well-described Parkinson’s-disease-associated gene, and it is important for maintaining cristae junctions and appears to control mitochondria-dependent apoptotic cell death, suggesting a possible involvement of this subcomplex in the pathogenesis of Parkinson’s disease (PD) [179]. This evidence concerns the gene PINK1 and Parkinson disease.