A recent report that used an Ins1cre knock-in allele to delete Insr, specifically in β-cells of both female and male mice, indicates that β-cell insulin resistance, characterized by decreased β-cell Insr, plays a role in hyperinsulinemia during glucose stimulation, thus enhancing glucose homeostasis regardless of gender and fed state in mice [237]. The gene discussed is INSR; the disease is Hyperinsulinemia.