RAC1 and central nervous system cancer: Figure 9b shows that pERM colocalizes with actin filaments with the formation of actin rings. It is important to note that the iper-phosphorylation of ERM proteins within minutes after a 1g injection has been observed for cell phenotypes other than glioma cells (for example for NIH-3T3). However, only in the case of U87MG, we observed a strong effect on cell morphology and neurite retraction. This finding is consistent with the results obtained by Areti A et al. [84], where a partnership between ERM and Rac-1 played an important role in neurite outgrowth.