EGFR and glioblastoma: In the same way, an IDH-wildtype astrocytoma falls under the group of glioblastomas in the presence of at least one of the following characteristics: necrosis and/or microvascular proliferation and/or TERT promoter mutation and/or EGFR gene amplification and/or concomitant gain of chromosome 7 and loss of chromosome 10 [28].