Recently, the PNPLA3 genotypes in addition to diabetes status were found to identify patients at a higher risk of cirrhosis among those at an indeterminate risk of MAFLD in two Caucasian cohorts [39], the clinical role of which has not been reproduced in a Korean biopsy-proven MAFLD cohort [40]. This evidence concerns the gene PNPLA3 and Cirrhosis.