GBM, IDH-wildtype: This classification identifies specific molecular markers for this tumor, such as the presence of a TERT promoter mutation (associated with increased telomerase activity, crucial for tumor cell immortalization) or EGFR gene amplification, leading to overexpression of the receptor and the combined gain of chromosome 7 and loss of chromosome 10 (+7/−10). This evidence concerns the gene IDH2 and neoplasm.