BMAL1 and Ventricular arrhythmia: Lack of CASQ1 causes malignant hyperthermia/environmental heat-stroke-like ventricular arrhythmias [75], while αMHCCREBmaL1fl/fl mouse CASQ1 and CASQ2 expression significantly increased [73], suggesting that the expression changes in CLOCK/BMAL1 circadian genes affect ventricular repolarization by regulating the expression of calcium channel genes in myocardial cells, leading to arrhythmias.