In another study, higher levels of proteomics-based soluble urokinase plasminogen activator receptor were significantly associated with the risk of incident all-cause, ischemic, and nonischemic HF risk, independent of NT-proBNP levels, CRP levels, and demographic and risk factor characteristics, which suggests that these levels may be valuable prognostic information [85]. This evidence concerns the gene NPPB and hydrops fetalis.