Several of the loci were additionally associated with HF risk factors, including PHACTR1, LPA, and CDKN2B-AS with coronary artery disease; FTO with body mass index, type 2 diabetes, and high-density lipoprotein (HDL) cholesterol; and BAG3 with diastolic blood pressure, further supporting their role in HF [18]. This evidence concerns the gene LPA and hydrops fetalis.