Additionally, increased plasma concentrations of suppression of tumorigenicity-2 (ST2), growth differentiation factor 15 (GDF-15), galectin-4 (Gal-4), and NT-proBNP were associated with incident HF but not consistently with left ventricular hypertrophy or diastolic dysfunction [39]. The gene discussed is LGALS4; the disease is left ventricular hypertrophy.