A tibial bone histomorphometric analysis revealed a significant decrease in cancellous bone volume, trabecular number and osteoblast surface per bone surface, together with an increase in osteoclast surface per bone surface and osteoclast number per bone perimeter, in WT-CKD mice, Mx1;TβRICA mice and Mx1;TβRICA-CKD mice compared to WT mice (Figure 6). The gene discussed is MX1; the disease is chronic kidney disease.