In the evolving field of cancer immunotherapy, particularly regarding prostate cancer, the exploration of medicinal mushrooms like AC, Sanghuangporus sanghuang, Ganoderma lucidum, Ganoderma sinense, and Inonotus obliquus offers a promising yet under-researched avenue, specifically in their interactions with the PD-L1 and PD-1 pathways. This evidence concerns the gene CD274 and prostate carcinoma.