Mutations in BRAF (rapidly accelerated fibrosarcoma B-type) and NRAS (neuroblastoma RAS viral oncogene homolog) are the most common genetic drivers of melanoma, with BRAFV600E occurring in over 50% of cases [5] and NRAS mutations, such as Q61R, observed in 15−20% of cases [6]. The gene discussed is NRAS; the disease is melanoma.