These mutations activate the MAPK (mitogen-activated protein kinase)/ERK (extracellular signal-regulated kinase signaling pathway (RAS, RAF, MEK1/2 (mitogen-activated extracellular signal-regulated kinase), and ERK1/2), promoting cell growth, proliferation, and migration, thus contributing to melanoma development and progression [5]. The gene discussed is MAPK1; the disease is melanoma.